111374-21-1
- CAS号:111374-21-1
- 英文名:HSR 6071
- 中文名:111374-21-1
- CBNumber:CB41369874
- 分子式:C10H12N8O
- 分子量:260.26
- MOL File:111374-21-1.mol
- 熔点 :288-294 °C (decomp)(Solv: dimethyl sulfoxide (67-68-5))
- 密度 :1.555±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 酸度系数(pKa) :2.61±0.10(Predicted)
- 颜色 :Light yellow to yellow
111374-21-1性质、用途与生产工艺
- 生物活性 HSR6071 是吡嗪甲酰胺衍生物，是一种具有口服活性的，有效的抗过敏剂。HSR6071 有效抑制大鼠模型的实验性哮喘。
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体内研究
The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea.
HSR-6071 inhibits the IgE-mediated histamine release with an IC 50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.
- 更新日期：2024/11/08
- 产品编号：HY-U00133
- 产品名称：111374-21-1 HSR6071
- CAS编号：111374-21-1
- 包装：1mg
- 价格：1590元
- 更新日期：2024/11/08
- 产品编号：HY-U00133
- 产品名称：111374-21-1 HSR6071
- CAS编号：111374-21-1
- 包装：5mg
- 价格：3500元
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
