多肽CREBtide
- CAS号:149155-45-3
- 英文名:CREBtide
- 中文名:多肽CREBtide
- CBNumber:CB41319905
- 分子式:C73H129N29O19
- 分子量:1716.99
- MOL File:149155-45-3.mol
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 颜色 :White to off-white
多肽CREBtide性质、用途与生产工艺
- 生物活性 CREBtide 是一种合成的含 13 个氨基酸的肽,作为一种 PKA 底物。
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靶点
PKA
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体外研究
delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent K m of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (K m =39 μM), the synthetic peptide substrate most often employed for cAK measurement. The V max values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent K m of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the V max value is 3.2 mumol/(min.mg). Both delta-CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide.
- 更新日期:2024/04/30
- 产品编号:HY-P1595A
- 产品名称:CREBtide TFA
- CAS编号:
- 包装:1 mg
- 价格:700元
- 更新日期:2024/04/30
- 产品编号:HY-P1595A
- 产品名称:CREBtide TFA
- CAS编号:
- 包装:5 mg
- 价格:2200元
- 公司名称:Creative Peptides
- 联系电话:
- 电子邮件:info@creative-peptides.com
- 国家:美国
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- 公司名称:BOC Sciences
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- 公司名称:Aladdin Scientific
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- 公司名称:MedChemExpress
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