ChemicalBook CAS数据库列表 2H4]-D,L-2-羟基戊二酸
2H4]-D,L-2-羟基戊二酸
![2H4]-D,L-2-羟基戊二酸,2889-31-8,结构式](https://www.chemicalbook.com/CAS/20180808/GIF/2889-31-8.gif)
- CAS号:2889-31-8
- 英文名:C02630
- 中文名:2H4]-D,L-2-羟基戊二酸
- CBNumber:CB41246373
- 分子式:C5H8O5
- 分子量:148.11
- MOL File:2889-31-8.mol
2H4]-D,L-2-羟基戊二酸化学性质
- 熔点 :98-100 °C(Solv: ethyl acetate (141-78-6))
- 沸点 :394.2±27.0 °C(Predicted)
- 密度 :1.508±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- 酸度系数(pKa) :3.67±0.10(Predicted)
2H4]-D,L-2-羟基戊二酸性质、用途与生产工艺
- 生物活性 α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。
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体外研究
Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin.
2H4]-D,L-2-羟基戊二酸上下游产品信息
上游原料
下游产品
2H4]-D,L-2-羟基戊二酸生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6088
- 优势度：71
