生物活性 靶点 体外研究 体内研究 奴文西平 试剂级价格
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奴文西平

奴文西平,96487-37-5,结构式
奴文西平
  • CAS号:96487-37-5
  • 英文名:Nuvenzepine
  • 中文名:奴文西平
  • CBNumber:CB41118339
  • 分子式:C19H20N4O2
  • 分子量:336.39
  • MOL File:96487-37-5.mol
奴文西平化学性质
  • 沸点 :522.3±50.0 °C(Predicted)
  • 密度 :1.267±0.06 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :Soluble in DMSO
  • 形态 :Solid
  • 酸度系数(pKa) :10.99±0.20(Predicted)
  • 颜色 :White to off-white

奴文西平性质、用途与生产工艺

  • 生物活性 Nuvenzepine是 mAChR 的拮抗剂,有潜力用于胃痉挛的研究。
  • 靶点

    mAChR

  • 体外研究

    Nuvenzepine shows a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions on isolated ileal musculature and on longitudinal ileum dispersed cells. Nuvenzepine is almost equipotent to pirenzepine in competitively preventing bethanechol-induced gall-bladder contractions and it displays a four-fold higher potency than pirenzepine in blocking vagal-stimulated tracheal constrictions.

  • 体内研究

    Intraduodenally administration of Nuvenzepine displays a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. On ileal motor activity, Nuvenzepine shows a potency 10 times greater than that of pirenzepine. Nuvenzepine is also active, unlike pirenzepine, on colonic stimulated motility. Furthermore, in conscious cats, Nuvenzepine inhibits pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine. Nuvenzepine has been found to be very active in inhibiting gastric acid secretion and intestinal hypermotility in rats, with very slight atropine-like side effects. The oral absorption rate is relatively slow, that the absolute bioavailability is 30 to 40%, that the elimination rate is slow and there is no accumulation in the body, and that there is very little metabolism.

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奴文西平 试剂级价格
  • 更新日期:2024/08/19
  • 产品编号:HY-U00119
  • 产品名称:奴文西平 Nuvenzepine
  • CAS编号:96487-37-5
  • 包装:1mg
  • 价格:1800元
  • 更新日期:2024/08/19
  • 产品编号:HY-U00119
  • 产品名称:奴文西平 Nuvenzepine
  • CAS编号:96487-37-5
  • 包装:5mg
  • 价格:4000元
奴文西平生产厂家
  • 公司名称:ChemeGen 中国
  • 联系电话: 18818260767
  • 电子邮件:sales@chemegen.com
  • 国家:中国
  • 产品数:11217
  • 优势度:58
  • 公司名称:广州优南科技有限公司
  • 联系电话:020-82000279 18988968278
  • 电子邮件:sales@ubiochem.com
  • 国家:中国
  • 产品数:4297
  • 优势度:58
  • 公司名称:TargetMol中国(陶术生物)
  • 联系电话: 4008200310
  • 电子邮件:marketing@tsbiochem.com
  • 国家:中国
  • 产品数:24649
  • 优势度:58
  • 公司名称:上海一飞生物科技有限公司
  • 联系电话:021-65675885 18964387627
  • 电子邮件:customer_service@efebio.com
  • 国家:中国
  • 产品数:11974
  • 优势度:58
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