AMUSTALINE DIHYDROCHLORIDE
- CAS号:210584-54-6
- 英文名:Amustaline Dihydrochloride
- 中文名:AMUSTALINE DIHYDROCHLORIDE
- CBNumber:CB41016699
- 分子式:C22H26Cl3N3O2
- 分子量:470.82
- MOL File:210584-54-6.mol
- 形态 :Solid
- 颜色 :Yellow to brown
AMUSTALINE DIHYDROCHLORIDE性质、用途与生产工艺
- 生物活性 Amustaline (S-303) dihydrochloride,一种靶向核酸的烷基化剂,是有效的病原体灭活剂,可用于含有红细胞的血液成分。Amustaline dihydrochloride 具有三个组成部分:吖啶固定物 (非共价靶向核酸的嵌入剂),效应子 (与亲核试剂反应的双烷基基团) 和连接子 (细的柔性碳链,其中含有不稳定的酯键,在中性 pH 下水解产生非反应性分解产物)。
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体外研究
S‐303 (200 μM; 20 h) and glutathione (GSH; 20 mM) inactivates high titres of Chikungunya virus (CHIKV) in red blood cells (RBCs).
S-303 (200 μM; 20 h) and GSH (2 mM) inactivates >6.5 logs of HIV, >5.7 logs of Bluetongue virus, >7.0 logs of Yersinia enterocolitica , 4.2 logs of Serratia marcescens , and 7.5 logs of Staphylococcus epidermidis in whole blood experiments .
S-303 (200 μM; 20 h) and GSH (20 mM) inactivates approximately 5 logs or greater of Y. enterocolitica , E. coli , S. marcescens , S. aureus , HIV, bovine viral diarrhoea virus, bluetongue virus and human adenovirus 5 in RBC.
S-303 (200 μM; 20 h) retains in vitro parameters of RBC function and physiology (including total ATP, extracellular potassium, hemolysis, glucose consumption, lactate production, and pH at 37 °C) compared to conventional RBC. -
体内研究
S‐303 RBCs (a single transfusion) is well tolerated in rats (50 μmol/kg) and dogs (70 μmol/kg).
S‐303 RBCs (repeated transfusions) is well tolerated in rats (10 μmol/kg) and dogs (10 μmol/kg) with no histopathologic evidence of organ toxicity.
- 更新日期:2024/08/19
- 产品编号:HY-106991A
- 产品名称:Amustaline dihydrochloride
- CAS编号:
- 包装:1 mg
- 价格:1818元
- 更新日期:2024/08/19
- 产品编号:HY-106991A
- 产品名称:AMUSTALINE DIHYDROCHLORIDE Amustaline dihydrochloride
- CAS编号:210584-54-6
- 包装:5mg
- 价格:4000元
- 公司名称:上海睿升化工科技有限公司
- 联系电话: 15026594951
- 电子邮件:rs@raise-chem.com
- 国家:中国
- 产品数:3494
- 优势度:55