4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐
- CAS号:23307-72-4
- 英文名:sodium N-(6-chloropyrazinyl)sulphanilamidate
- 中文名:4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐
- CBNumber:CB3921924
- 分子式:C10H10ClN4NaO2S
- 分子量:308.72
- MOL File:23307-72-4.mol
- 储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
- 溶解度 :DMF: 1 mg/ml; DMSO: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
- 形态 :Solid
- 颜色 :Light yellow to yellow
- WGK Germany :3
4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐性质、用途与生产工艺
- 生物活性 Sulfaclozine sodium (Sulfachloropyrazine sodium) 是一种有效的磺酰胺衍生物，具有抗菌和抗球虫作用。Sulfaclozine sodium 通常用于各种家禽疾病(尤其是结肠杆菌病，禽霍乱和球虫病)的相关研究。
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靶点
Bacterial; Parasite
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体外研究
The elimination of Sulfaclozine in the three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 . Sulfaclozine is weakly adsorbed on the surface of TiO 2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of • OH and SO 4 •− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.
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体内研究
Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.
Animal Model: 14 male broiler chickens (30-day-old) Dosage: 60 mg/kg Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis) Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
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