诺次黄嘌呤外消旋体
- CAS号:75166-67-5
- 英文名:1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-6H-purin-6-one
- 中文名:诺次黄嘌呤外消旋体
- CBNumber:CB3917695
- 分子式:C14H22N4O2
- 分子量:278.35
- MOL File:75166-67-5.mol
- 沸点 :539.1±30.0 °C(Predicted)
- 密度 :1.27±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 酸度系数(pKa) :8.84±0.70(Predicted)
诺次黄嘌呤外消旋体性质、用途与生产工艺
- 生物活性 Nosantine racemate 是 Nosantine 的外消旋体。Nosantine是一种 IL-2 诱导剂或诱导 IL-2 的增强剂。
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靶点
IL-2
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体外研究
The purine immunoenhancing drug Nosantine (NPT 15392) is evaluated as an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA). Nosantine is found to has significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations.
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体内研究
Multiple concomitant immune responses are assessed in individual rats following treatment with the immunoenhancing drugs, Isoprinosine (5 or 50 mg/kg), Nosantine (0.1 or 1.0 mg/kg) and Avridine (1 or 25 mg/kg), or the immunosuppressant, Cyclophosphamide (75 mg/kg). Rats treated with Nosantine (NPT 15392) have significantly enhanced DTH reactions at the 0.1 mg/kg dose. It can be concluded that NPT 15392 act as general immunostimulants in the rat, with avridine having the greatest effect under these experimental conditions.
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- 国家：美国
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- 公司名称：MedChemExpress
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- 国家：美国
- 产品数：6398
- 优势度：58
