Duocarmycin DM
- CAS号:
- 英文名:Duocarmycin DM
- 中文名:
- CBNumber:CB39041494
- 分子式:
- 分子量:0
- MOL File:Mol file
Duocarmycin DM性质、用途与生产工艺
- 生物活性 Duocarmycin DM 是一种 DNA 小沟烷基化剂 (DNA minor-groove alkylator)，是一种抗体药物结合物 (ADCs) 毒素。Duocarmycin DM 因特有的结构而具有抗癌活性。
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靶点
Daunorubicins/Doxorubicins
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体外研究
The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from Streptomyces sp. that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture.
Duocarmycin DM shows cytotoxicity to several human cancer cells, with IC 50 of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively.
Duocarmycin DM上下游产品信息
上游原料
下游产品
Duocarmycin DM生产厂家
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
