CS-1506

生物活性靶点体外研究体内研究 CS-1506 试剂级价格

CS-1506

CAS号:210345-04-3
英文名:Z-LEHD-FMK
中文名:CS-1506
CBNumber:CB3758272
分子式:C32H43FN6O10
分子量:690.73
MOL File:Mol file

CS-1506化学性质

沸点 :1008.2±65.0 °C(Predicted)
密度 :1.272±0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO.
形态 :powder
酸度系数(pKa) :11.11±0.46(Predicted)
颜色 :White to yellow

安全信息

WGK Germany :3

CS-1506性质、用途与生产工艺

生物活性 Z-LEHD-FMK 是一种选择性和不可逆的 caspase-9 抑制剂，可防止致命的再灌注损伤并减弱细胞凋亡。Z-LEHD-FMK 在大鼠脊髓损伤模型中也表现出神经保护作用。
靶点

Caspase-9

体外研究

Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.
Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.

Apoptosis Analysis

Cell Line:	SW480, H460, HCT116 and 293 cells
Concentration:	20 μM
Incubation Time:	Pretreated for 30 min
Result:	Protected HCT116 and 293 cells from TRAIL-induced apoptosis.

Western Blot Analysis

Cell Line:	HCT116, SW480 cells
Concentration:	20 μM
Incubation Time:	2 h
Result:	Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point.

体内研究

Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.

Animal Model:	Male Wistar albino rats (250-350 g) with SCI
Dosage:	0.8 μmol/kg
Administration:	I.v. for 1 or 7 days
Result:	Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.