增免疫苏精肽
- CAS号:72103-53-8
- 英文名:TUFTSIN ACETATE SALT
- 中文名:增免疫苏精肽
- CBNumber:CB3716403
- 分子式:C23H44N8O8
- 分子量:560.64
- MOL File:72103-53-8.mol
- 储存条件 :−20°C
- WGK Germany :3
增免疫苏精肽性质、用途与生产工艺
- 生物活性 Tuftsin diacetate 是一种四肽,是巨噬细胞/小胶质细胞 (macrophage/microglial) 的激活剂。
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体外研究
Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors.
- 更新日期:2024/08/19
- 产品编号:HY-P0240
- 产品名称:Tuftsin
- CAS编号:
- 包装:1 mg
- 价格:228元
- 更新日期:2024/08/19
- 产品编号:HY-P0240
- 产品名称:增免疫苏精肽 Tuftsin
- CAS编号:72103-53-8
- 包装:5mg
- 价格:550元
- 公司名称:SIGMA
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- 国家:瑞士
- 产品数:6913
- 优势度:91