兔抗IL-6抗体
- CAS号:
- 英文名:Rabbit Anti-Human IL-6
- 中文名:兔抗IL-6抗体
- CBNumber:CB35683838
- 分子式:
- 分子量:0
- MOL File:Mol file
兔抗IL-6抗体性质、用途与生产工艺
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描述
兔多克隆抗体to IL-6
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宿主
Rabbit
- 种属反应性 与反应: Human
- 免疫原 Recombinant full length protein corresponding to Human IL-6. Produced in E.coli.
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验证的应用
适用于: WB, IHC-P
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制备
Produced in rabbits immunized with purified, recombinant Human IL6 / IL-6 . IL6 / IL-6 specific IgG was purified by Human IL6 / IL-6 affinity chromatography.
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品牌示例
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-6 antibody (ab6672)
IL6 (Red) and IL-12 (Green) were measured at 1, 3, and 7 days after 10 Gy irradiation of HCa-1 tumors to determine whether irradiation regulates IL-12 and IL6 expression in tumours. ab6672 was used to stain IL6 at 1/100 dilution in immunohistochemical analysis.
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背景
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 13 (gp13) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
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简介
兔抗人IL-6抗体是以人IL-6为抗原以兔为宿主制得的免疫抗体,可以特异性结合人IL-6,主要用于检测人IL-6的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。
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