兔抗IL-6抗体

兔多克隆抗体to IL-6

Rabbit

适用于: WB, IHC-P

Produced in rabbits immunized with purified, recombinant Human IL6 / IL-6 . IL6 / IL-6 specific IgG was purified by Human IL6 / IL-6 affinity chromatography.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-6 antibody (ab6672)

IL6 (Red) and IL-12 (Green) were measured at 1, 3, and 7 days after 10 Gy irradiation of HCa-1 tumors to determine whether irradiation regulates IL-12 and IL6 expression in tumours. ab6672 was used to stain IL6 at 1/100 dilution in immunohistochemical analysis.

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 13 (gp13) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

兔抗人IL-6抗体是以人IL-6为抗原以兔为宿主制得的免疫抗体，可以特异性结合人IL-6，主要用于检测人IL-6的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。