化合物 2-FUROYL-LIGRLO-AMIDE TFA
- CAS号:2468029-34-5
- 英文名:2-Furoyl-LIGRLO-amide TFA
- 中文名:化合物 2-FUROYL-LIGRLO-AMIDE TFA
- CBNumber:CB35540609
- 分子式:
- 分子量:0
- MOL File:Mol file
化合物 2-FUROYL-LIGRLO-AMIDE TFA性质、用途与生产工艺
- 生物活性 2-Furoyl-LIGRLO-amide TFA 是一种有效的选择性蛋白酶激活受体2 (PAR2) 激动剂， 其 pD2 值为 7.0。
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靶点
Proteinase-activated receptor 2 (PAR2)
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体外研究
2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH 2 ) is equally effective to and 10 to 25 times more potent than SLIGRLNH 2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively.
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH 2 ) is 10 to 300 times more potent than SLIGRL-NH 2 . Unlike trans-cinnamoyl-LIGRLO-NH 2 , 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries. -
体内研究
Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3 -/- mice. But it decreases significantly the number of scratches in WT mice.
Animal Model: Adult male (2/3-month-old) Trpv3 -/- and WT mice Dosage: 10 μg Administration: Injected intradermally at the nape of the neck Result: Was involved in PAR2- induced acute itch.
- 更新日期：2023/03/20
- 产品编号：HY-P1314A
- 产品名称：2-Furoyl-LIGRLO-amide TFA
- CAS编号：
- 包装：1mg
- 价格：1200元
- 更新日期：2023/03/20
- 产品编号：HY-P1314A
- 产品名称：2-Furoyl-LIGRLO-amide TFA
- CAS编号：
- 包装：5mg
- 价格：3600元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话： +8613564774135
- 电子邮件：zijue.cai@tsbiochem.com
- 国家：美国
- 产品数：19881
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
