ChemicalBook CAS数据库列表 七尾霉素
七尾霉素
- CAS号:52934-83-5
- 英文名:NANAOMYCIN A
- 中文名:七尾霉素
- CBNumber:CB3503991
- 分子式:C16H14O6
- 分子量:302.28
- MOL File:52934-83-5.mol
七尾霉素化学性质
- 熔点 :179°C
- 沸点 :363.32°C (rough estimate)
- 密度 :1.2514 (rough estimate)
- 折射率 :1.4600 (estimate)
- 储存条件 :−20°C
- 溶解度 :insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic
- 形态 :solid
- 颜色 :Yellow to orange
安全信息
七尾霉素性质、用途与生产工艺
- 生物活性 Nanaomycin A 是第一个选择性 DNMT3B 抑制剂，IC50 为 500 nM。Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的抑癌基因。Nanaomycin A 抑制人疟原虫恶性疟原虫的体外生长，IC80 值为 33.1 nM。
-
靶点
DNMT3B
500 nM (IC 50 )
-
体外研究
Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines.
Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells.
Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction.
Nanaomycin A not affects the enzymatic activity of DNMT1.
Cell Cytotoxicity Assay
Cell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines Concentration: 10, 100, 1000, 10000 nM Incubation Time: 72 hours Result: Had a distinct cytotoxic effect in all three cell lines. Western Blot Analysis
Cell Line: A549 cells Concentration: 0.5, 5 μM Incubation Time: 72 hours Result: Revealed induction of RASSF1A protein expression. RT-PCR
Cell Line: A549 cells Concentration: 5 μM Incubation Time: 72 hours Result: Had an 18-fold relative induction.
七尾霉素上下游产品信息
上游原料
下游产品
七尾霉素生产厂家
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
52934-83-5, 七尾霉素相关搜索:
