Alamandine
- CAS号:1176306-10-7
- 英文名:Alamandine
- 中文名:Alamandine
- CBNumber:CB34668988
- 分子式:C40H62N12O9
- 分子量:855
- MOL File:1176306-10-7.mol
- 密度 :1.42±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 酸度系数(pKa) :3.28±0.20(Predicted)
- 颜色 :White to off-white
Alamandine性质、用途与生产工艺
- 生物活性 Alamandine 是一种血管活性肽，是肾素-血管紧张素系统 (RAS) 的成员，还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。
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体外研究
Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood.
Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling.
Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes. -
体内研究
Alamandine (0.15 μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide.
Animal Model: Male spontaneously hypertensive rats (SHRs, 50-week-old) Dosage: 0.15 μL/h (~50 μg/kg/day) Administration: Administered by mini-osmotic pumps; for 6 weeks Result: Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function.
- 更新日期：2024/04/30
- 产品编号：HY-P3108
- 产品名称：Alamandine
- CAS编号：
- 包装：1 mg
- 价格：1727元
- 更新日期：2024/04/30
- 产品编号：HY-P3108
- 产品名称：Alamandine Alamandine
- CAS编号：1176306-10-7
- 包装：5mg
- 价格：3800元
- 公司名称：BOC Sciences
- 联系电话：16314854226; +16314854226
- 电子邮件：inquiry@bocsci.com
- 国家：美国
- 产品数：19743
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52927
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
