ChemicalBook CAS数据库列表 ALLOSTERIC WNK KINASE INHIBITOR
ALLOSTERIC WNK KINASE INHIBITOR
- CAS号:2123489-30-3
- 英文名:Allosteric WNK Kinase Inhibitor ,
- 中文名:ALLOSTERIC WNK KINASE INHIBITOR
- CBNumber:CB34664001
- 分子式:C21H21Cl2N5OS
- 分子量:462.4
- MOL File:2123489-30-3.mol
ALLOSTERIC WNK KINASE INHIBITOR化学性质
- 沸点 :641.1±65.0 °C(Predicted)
- 密度 :1.407±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :5.52±0.10(Predicted)
- 颜色 :White to off-white
ALLOSTERIC WNK KINASE INHIBITOR性质、用途与生产工艺
- 生物活性 WNK-IN-11 是一种有效的、具有选择性的 With-No-Lysine (WNK) 的口服活性变构抑制剂，对WNK1酶的IC50为4 nM。
-
靶点
Target Value WNK1
(Cell-free assay)4 nM -
体外研究
WNK-IN-11 (compound 11) shows IC 50 <2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC 50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.
ALLOSTERIC WNK KINASE INHIBITOR上下游产品信息
上游原料
下游产品
ALLOSTERIC WNK KINASE INHIBITOR 试剂级价格
- 更新日期：2024/04/30
- 产品编号：HY-112094
- 产品名称：ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11
- CAS编号：2123489-30-3
- 包装：10mM * 1mLin DMSO
- 价格：2340元
- 更新日期：2024/04/30
- 产品编号：S0015
- 产品名称：ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11
- CAS编号：2123489-30-3
- 包装：5mg
- 价格：3550.96元
ALLOSTERIC WNK KINASE INHIBITOR生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6124
- 优势度：58
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