生物活性 靶点 体外研究 体内研究 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE 试剂级价格
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
ChemicalBook  CAS数据库列表  1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

生物活性 靶点 体外研究 体内研究 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE 试剂级价格
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE,174689-39-5,结构式
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
  • CAS号:174689-39-5
  • 英文名:1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
  • 中文名:1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
  • CBNumber:CB3331761
  • 分子式:C23H29NO6
  • 分子量:415.49
  • MOL File:174689-39-5.mol
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE化学性质
  • 储存条件 :Inert atmosphere,Room Temperature
  • 溶解度 :DMSO: >10mg/mL
  • 形态 :powder
  • 颜色 :white
安全信息

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE性质、用途与生产工艺

  • 生物活性 SR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂，对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。
  • 靶点
    TargetValue
    β3-adrenergic receptor
    (Cell-free assay)     		40 nM
    β1-adrenergic receptor
    (Cell-free assay)     		408 nM
    β2-adrenergic receptor
    (Cell-free assay)     		648 nM
  • 体外研究

    SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.

    Cell Viability Assay

    Cell Line: Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C)
    Concentration: 100 nM, 1 μM, 5 μM, 10 μM, and 50 μM
    Incubation Time: 24 hours
    Result: Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1 µM for Neuro-2A cells and 5 µM for SK-N-BE(2) and BE(2)C).
  • 体内研究

    MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.

    Animal Model: Male C-57BL6J wild-type mice (22-35 g)
    Dosage: 0.5 or 5 mg/kg
    Administration: Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).
    Result: Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE上下游产品信息
上游原料
下游产品
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-103200
  • 产品名称：1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE SR59230A hydrochloride
  • CAS编号：174689-39-5
  • 包装：5mg
  • 价格：1000元
  • 更新日期：2024/11/08
  • 产品编号：HY-103200
  • 产品名称：1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE SR59230A hydrochloride
  • CAS编号：174689-39-5
  • 包装：10mM * 1mLin DMSO
  • 价格：1100元
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE生产厂家
  • 公司名称：Labinova AB
  • 联系电话：--
  • 电子邮件：info@labinova.se
  • 国家：欧洲
  • 产品数：281
  • 优势度：64
关注Chemicalbook 进入官方账号