ChemicalBook CAS数据库列表 化合物 T22720
化合物 T22720
- CAS号:15332-10-2
- 英文名:DFB
- 中文名:化合物 T22720
- CBNumber:CB3322679
- 分子式:C14H10F2N2
- 分子量:244.24
- MOL File:15332-10-2.mol
化合物 T22720化学性质
- 沸点 :326.6±42.0 °C(Predicted)
- 密度 :1.12±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: ~12 mg/mL
- 酸度系数(pKa) :5.78±0.50(Predicted)
- 形态 :solid
- 颜色 :yellow
安全信息
化合物 T22720性质、用途与生产工艺
- 生物活性 3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC50 在 2 到 5 μM 范围内。
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体外研究
3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC 50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies.
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体内研究
3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
Animal Model: Male NMRI and ICR mice (8-9 weeks, 33-40 g) Dosage: 40-100 nmol (~9.7-24.4 μg) Administration: ICV Result: Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
化合物 T22720上下游产品信息
上游原料
下游产品
化合物 T22720生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6913
- 优势度：91
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