413599-62-9
- CAS号:413599-62-9
- 英文名:ZD-4190
- 中文名:413599-62-9
- CBNumber:CB33175607
- 分子式:C19H16BrFN6O2
- 分子量:459.27
- MOL File:413599-62-9.mol
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : 20.83 mg/mL (45.35 mM);Water : < 0.1 mg/mL (insoluble)
413599-62-9性质、用途与生产工艺
- 生物活性 ZD-4190是VEGF RTK抑制剂,对KDR和Flt-1的IC50值分别为29 ± 4 nM和708 ± 63 nM。
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靶点
Target Value KDR
()Flt-1
() -
体外研究
ZD4190 exhibits cytotoxic activity against the tumor cells.
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体内研究
ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, 18F-FPPRGD2 uptake has decreased significantly relative to baseline by 26.74±8.12% (p<0.05) on day 1 and by 41.19±6.63% (p<0.01) on day 3, then has returned to baseline on day 7. Tumor uptake of 18F-FLT has also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. However, ZD4190 does not significantly change 18F-FDG uptake in tumors, compared with the control group. ZD4190 (50 mg/kg, p.o.) prevents outgrowth of residual tumour in a muscle model of minimal residual carcinoma. ZD4190 (12.5-100 mg/kg, p.o.) produces a dose-dependent reduction in K(trans) in PC-3 prostate tumors. At 100 mg/kg, ZD4190 reduces K(trans) in PC-3 tumors by 31% following 2 doses and by 53% following 8 doses.
- 更新日期:2024/04/30
- 产品编号:HY-U00002
- 产品名称:ZD-4190
- CAS编号:
- 包装:1 mg
- 价格:850元
- 更新日期:2024/04/30
- 产品编号:HY-U00002
- 产品名称:413599-62-9 ZD-4190
- CAS编号:413599-62-9
- 包装:5mg
- 价格:2200元
- 公司名称:MedChemexpress LLC
- 联系电话:021-58955995
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- 国家:美国
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- 公司名称:Aladdin Scientific
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- 公司名称:TargetMol Chemicals Inc.
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- 电子邮件:support@targetmol.com
- 国家:美国
- 产品数:19973
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- 公司名称:MedChemExpress
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- 国家:美国
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