ChemicalBook CAS数据库列表 145841-10-7
145841-10-7
- CAS号:145841-10-7
- 英文名:Sch-42495 (racemate)
- 中文名:145841-10-7
- CBNumber:CB33175586
- 分子式:C20H29NO4S2
- 分子量:411.58
- MOL File:145841-10-7.mol
145841-10-7化学性质
- 沸点 :597.3±50.0 °C(Predicted)
- 密度 :1.158±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 酸度系数(pKa) :13.50±0.46(Predicted)
145841-10-7性质、用途与生产工艺
- 生物活性 SCH 42495 racemate 是 Sch-42495 的外消旋体。SCH 42495 是一种具有口服活性的中性金属内肽酶 (NEP) 抑制剂，具有抗高血压活性。SCH 42495 是 SCH 42354 的口服活性前药。
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靶点
NEP
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体外研究
SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF (IC 50 of 8.3 and 10.0 nM, respectively) in vitro.
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体内研究
SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days.
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats.
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively.Animal Model: Hypoxic rats Dosage: 30 mg/kg Administration: Oral gavage; twice daily for 10 days Result: Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy.
Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia.
145841-10-7上下游产品信息
上游原料
下游产品
145841-10-7生产厂家
- 公司名称：天津普西唐生物医药科技有限公司
- 联系电话：010-60605840 15801484223;
- 电子邮件：psaitong@jm-bio.com
- 国家：中国
- 产品数：29778
- 优势度：58
- 公司名称：TargetMol中国（陶术生物）
- 联系电话： 4008200310
- 电子邮件：marketing@tsbiochem.com
- 国家：中国
- 产品数：21667
- 优势度：58
