Volixibat potassium

Volixibat potassium化学性质

Volixibat potassium性质、用途与生产工艺

生物活性 Angstrom6 (A6 Peptide) 是一种来源于单链尿激酶纤溶酶原激活剂 (scuPA) 的8个氨基酸的肽，可干扰 uPA/uPAR 级联反应并消除下游效应。Angstrom6 与 CD44 结合，抑制肿瘤细胞的迁移、侵袭和转移，调节 CD44 介导的细胞信号。
体外研究

Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC ₅₀ s in the range of 10 to 100 nM.
Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation.

体内研究

Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%.

Animal Model:	C57Bl/6 mice (bearing B16-F10 cells)
Dosage:	100 mg/kg
Administration:	S.c.; twice a day for 11 days
Result:	Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.

Volixibat potassium上下游产品信息

上游原料

下游产品

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