66225-78-3

CAS号:66225-78-3
英文名:2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid
中文名:66225-78-3
CBNumber:CB33070724
分子式:C26H43NO6
分子量:465.62
MOL File:66225-78-3.mol

66225-78-3化学性质

沸点 :673.4±55.0 °C(Predicted)
密度 :1.213±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
形态 :A crystalline solid
酸度系数(pKa) :3.58±0.10(Predicted)
颜色 :White to off-white

66225-78-3性质、用途与生产工艺

生物活性 Gly-β-MCA 是一种胆汁酸，是有效的、稳定的、肠特异性的以及具有口服生物活性的法尼酯X受体 (FXR) 抑制剂，可用于代谢障碍的研究。
靶点

FXR.
体外研究

Gly-β-MCA, a bile acid, is a potent, sable and intestine-selective and farnesoid X receptor (FXR) inhibitor.
Gly-β-MCA (Gly-MCA, ) is resistant to hydrolysis by BSH.
体内研究

Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice.
Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation.

66225-78-3上下游产品信息

上游原料

下游产品

66225-78-3 试剂级价格

66225-78-3生产厂家