11H-茚并[1,2-b]喹喔啉-11-酮肟
- CAS号:23146-22-7
- 英文名:IQ-1 sodium
- 中文名:11H-茚并[1,2-b]喹喔啉-11-酮肟
- CBNumber:CB32750498
- 分子式:C15H9N3O
- 分子量:247.25
- MOL File:23146-22-7.mol
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :DMSO: soluble2mg/mL, clear (warmed)
- 形态 :powder
- 颜色 :white to beige
- WGK Germany :3
- 海关编码 :2933998090
11H-茚并[1,2-b]喹喔啉-11-酮肟性质、用途与生产工艺
- 生物活性 IQ-1S是JNK3抑制剂,对JNK3、JNK2、JNK1的Kd值分别为87 nM、360 nM和390 nM。
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靶点
Target Value JNK3
(Cell-free assay)87 nM JNK2
(Cell-free assay)360 nM JNK1
(Cell-free assay)390 nM -
体外研究
Compound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%.
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体内研究
When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1S) i.p., the serum exposure of the compound is also good, with AUC 0-12h values of 2.9 and 7.4 μM/h, respectively.
- 更新日期:2024/11/08
- 产品编号:HY-100233
- 产品名称:11H-茚并[1,2-b]喹喔啉-11-酮肟 IQ-1S free acid
- CAS编号:23146-22-7
- 包装:5mg
- 价格:500元
- 更新日期:2024/11/08
- 产品编号:HY-100233
- 产品名称:IQ-1S free acid
- CAS编号:
- 包装:10 mM * 1 mLin DMSO
- 价格:550元
- 公司名称:TCI Europe
- 联系电话:320-37350700
- 电子邮件:sales@tcieurope.eu
- 国家:欧洲
- 产品数:23671
- 优势度:75