生物活性 靶点 体外研究 体内研究 11H-茚并[1,2-b]喹喔啉-11-酮肟 试剂级价格
ChemicalBook  CAS数据库列表  11H-茚并[1,2-b]喹喔啉-11-酮肟

11H-茚并[1,2-b]喹喔啉-11-酮肟

11H-茚并[1,2-b]喹喔啉-11-酮肟,23146-22-7,结构式
11H-茚并[1,2-b]喹喔啉-11-酮肟
  • CAS号:23146-22-7
  • 英文名:IQ-1 sodium
  • 中文名:11H-茚并[1,2-b]喹喔啉-11-酮肟
  • CBNumber:CB32750498
  • 分子式:C15H9N3O
  • 分子量:247.25
  • MOL File:23146-22-7.mol
11H-茚并[1,2-b]喹喔啉-11-酮肟化学性质
  • 储存条件 :Sealed in dry,2-8°C
  • 溶解度 :DMSO: soluble2mg/mL, clear (warmed)
  • 形态 :powder
  • 颜色 :white to beige
安全信息
  • WGK Germany :3
  • 海关编码 :2933998090

11H-茚并[1,2-b]喹喔啉-11-酮肟性质、用途与生产工艺

  • 生物活性 IQ-1S是JNK3抑制剂,对JNK3、JNK2、JNK1的Kd值分别为87 nM、360 nM和390 nM。
  • 靶点
    TargetValue
    JNK3
    (Cell-free assay)
    87 nM
    JNK2
    (Cell-free assay)
    360 nM
    JNK1
    (Cell-free assay)
    390 nM
  • 体外研究

    Compound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%.

  • 体内研究

    When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1S) i.p., the serum exposure of the compound is also good, with AUC 0-12h values of 2.9 and 7.4 μM/h, respectively.

11H-茚并[1,2-b]喹喔啉-11-酮肟上下游产品信息
上游原料
下游产品
11H-茚并[1,2-b]喹喔啉-11-酮肟 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-100233
  • 产品名称:11H-茚并[1,2-b]喹喔啉-11-酮肟 IQ-1S free acid
  • CAS编号:23146-22-7
  • 包装:5mg
  • 价格:500元
  • 更新日期:2024/11/08
  • 产品编号:HY-100233
  • 产品名称:IQ-1S free acid
  • CAS编号:
  • 包装:10 mM * 1 mLin DMSO
  • 价格:550元
11H-茚并[1,2-b]喹喔啉-11-酮肟生产厂家
  • 公司名称:TCI Chemicals (India) Pvt. Ltd.
  • 联系电话:--
  • 电子邮件:sales-in@tcichemicals.com
  • 国家:印度
  • 产品数:6768
  • 优势度:58
  • 公司名称:A.J Chemicals
  • 联系电话:--
  • 电子邮件:sales@ajchem.in
  • 国家:印度
  • 产品数:6100
  • 优势度:58