ChemicalBook CAS数据库列表 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE

CAS号:837422-57-8
英文名:WH-4-023
中文名:2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
CBNumber:CB32710784
分子式:C32H36N6O4
分子量:568.67
MOL File:837422-57-8.mol

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE化学性质

沸点 :743.2±70.0 °C(Predicted)
密度 :1.247±0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO (60 mg/ml)
酸度系数(pKa) :7.89±0.42(Predicted)
形态 :powder
颜色 :white to beige
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.

安全信息

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE性质、用途与生产工艺

生物活性 WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) 是一种有效的，口服具有活性的Lck/Src抑制剂，无细胞试验中IC50分别为2 nM 和 6 nM。对p38α和KDR的选择性低300倍以上，还能有效抑制SIK（对SIK1、2、3的IC50分别为10、22、60 nM）。
靶点
Target Value
Lck
(Cell-free assay) 2 nM
Src
(Cell-free assay) 6 nM
体外研究
WH-4-023对p38 和 KDR显示出低活性。

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE上下游产品信息

上游原料

下游产品

更新日期：2024/11/08
产品编号：HY-12299
产品名称：2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE WH-4-023
CAS编号：837422-57-8
包装：5mg
价格：800元

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE生产厂家

837422-57-8, 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE相关搜索: