ChemicalBook CAS数据库列表 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
生物活性 靶点 体内研究
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 试剂级价格
![2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate,1181083-81-7,结构式](https://www.chemicalbook.com/CAS/20150408/GIF/1181083-81-7.gif)
- CAS号:1181083-81-7
- 英文名:2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
- 中文名:2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
- CBNumber:CB32704143
- 分子式:C19H21FN4O3S
- 分子量:404.46
- MOL File:1181083-81-7.mol
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate化学性质
- 沸点 :553.7±60.0 °C(Predicted)
- 密度 :1.47±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C(protect from light)
- 溶解度 :DMSO:23.74(Max Conc. mg/mL);58.7(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
Ethanol:2.02(Max Conc. mg/mL);4.99(Max Conc. mM) - 形态 :A crystalline solid
- 酸度系数(pKa) :1.29±0.20(Predicted)
- 颜色 :Off-white to yellow
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate性质、用途与生产工艺
- 生物活性 CLP290 是一种神经特异性 K+-Cl− 共转运体 KCC2 的口服激活剂，具有研究多种神经和精神疾病的潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。
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靶点
KCC2
-
体内研究
CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl - transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat.
Animal Model: Adult male rats (300 g, >postnatal day 60) Dosage: 100 mg/kg Administration: Oral gavage; 100 mg/kg; twice a day; 7day Result: Rescued established MIH and prevented its development by restoring Cl - transport or preventing its deficiency in the SDH.
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate上下游产品信息
上游原料
下游产品
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-103023
- 产品名称：CLP290
- CAS编号：
- 包装：1 mg
- 价格：377元
- 更新日期：2024/11/08
- 产品编号：HY-103023
- 产品名称：2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate CLP290
- CAS编号：1181083-81-7
- 包装：10mM * 1mLin DMSO
- 价格：740元
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
