生物活性 靶点 体内研究 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 试剂级价格
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ChemicalBook  CAS数据库列表  2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate

2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate

生物活性 靶点 体内研究 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 试剂级价格
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate,1181083-81-7,结构式
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
  • CAS号:1181083-81-7
  • 英文名:2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
  • 中文名:2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
  • CBNumber:CB32704143
  • 分子式:C19H21FN4O3S
  • 分子量:404.46
  • MOL File:1181083-81-7.mol
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate化学性质
  • 沸点 :553.7±60.0 °C(Predicted)
  • 密度 :1.47±0.1 g/cm3(Predicted)
  • 储存条件 :2-8°C(protect from light)
  • 溶解度 :DMSO:23.74(Max Conc. mg/mL);58.7(Max Conc. mM)
    DMSO:PBS (pH 7.2) (1:6):1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
    DMF:1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
    Ethanol:2.02(Max Conc. mg/mL);4.99(Max Conc. mM)
  • 形态 :A crystalline solid
  • 酸度系数(pKa) :1.29±0.20(Predicted)
  • 颜色 :Off-white to yellow

2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate性质、用途与生产工艺

  • 生物活性 CLP290 是一种神经特异性 K+-Cl− 共转运体 KCC2 的口服激活剂，具有研究多种神经和精神疾病的潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。
  • 靶点

    KCC2

  • 体内研究

    CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl - transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat.

    Animal Model: Adult male rats (300 g, >postnatal day 60)
    Dosage: 100 mg/kg
    Administration: Oral gavage; 100 mg/kg; twice a day; 7day
    Result: Rescued established MIH and prevented its development by restoring Cl - transport or preventing its deficiency in the SDH.
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate上下游产品信息
上游原料
下游产品
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-103023
  • 产品名称：CLP290
  • CAS编号：
  • 包装：1 mg
  • 价格：377元
  • 更新日期：2024/11/08
  • 产品编号：HY-103023
  • 产品名称：2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate CLP290
  • CAS编号：1181083-81-7
  • 包装：10mM * 1mLin DMSO
  • 价格：740元
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate生产厂家
  • 公司名称：上海超岚化工科技中心
  • 联系电话：021-QQ：65489617 15618227136
  • 电子邮件：Sales@ATKchemical.com
  • 国家：中国
  • 产品数：7268
  • 优势度：58
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