ChemicalBook CAS数据库列表 BMS303141
BMS303141
- CAS号:943962-47-8
- 英文名:BMS 303141
- 中文名:BMS303141
- CBNumber:CB32627606
- 分子式:C19H15Cl2NO4S
- 分子量:424.3
- MOL File:943962-47-8.mol
BMS303141化学性质
- 沸点 :591.5±60.0 °C(Predicted)
- 密度 :1.462±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble20mg/mL, clear
- 酸度系数(pKa) :4.94±0.48(Predicted)
- 形态 :powder
- 颜色 :white to beige
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
安全信息
- WGK Germany :3
BMS303141性质、用途与生产工艺
- 生物活性 BMS-303141 是一种有效的细胞渗透性的 ATP-citrate lyase (ACL) 抑制剂，其IC50值为0.13 μM。BMS-303141 可在HepG2细胞中抑制总脂质合成，其IC50值为8 μM。
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靶点
Target Value ACL
(Cell-free assay)0.13 μM -
体外研究
In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC 50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity.
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体内研究
Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h.
BMS303141上下游产品信息
上游原料
下游产品
BMS303141 试剂级价格
- 更新日期：2025/02/08
- 产品编号：HY-16107
- 产品名称：BMS-303141
- CAS编号：943962-47-8
- 包装：1 mg
- 价格：295元
- 更新日期：2025/02/08
- 产品编号：HY-16107
- 产品名称：BMS303141 BMS-303141
- CAS编号：943962-47-8
- 包装：5mg
- 价格：650元
BMS303141生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
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