ChemicalBook CAS数据库列表 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷
![1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷,66504-40-3,结构式](https://www.chemicalbook.com/CAS/GIF/66504-40-3.gif)
- CAS号:66504-40-3
- 英文名:1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
- 中文名:1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷
- CBNumber:CB32561096
- 分子式:C11H11Cl2N
- 分子量:228.12
- MOL File:66504-40-3.mol
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷化学性质
- 沸点 :324.4±37.0 °C(Predicted)
- 密度 :1.371
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : ≥ 125 mg/mL (547.96 mM);Water : < 0.1 mg/mL (insoluble)
- 酸度系数(pKa) :10.45±0.40(Predicted)
- 形态 :Oil
- 颜色 :Colorless to light yellow
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷性质、用途与生产工艺
- 生物活性 DOV-216,303 (Free Base) 是有效的 5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对 hSERT、hNET 和 hDAT 的 IC50 值分别为 14 nM，20 nM和78 nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。
-
靶点
IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine).
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体内研究
Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations.Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery. Dosage: 20 mg/kg. Administration: I.P. daily for 17days. Result: Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations. Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery. Dosage: 20 mg/kg. Administration: I.P. once. Result: Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷上下游产品信息
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1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 试剂级价格
- 更新日期：2024/04/30
- 产品编号：HY-18332C
- 产品名称：DOV-216,303 Free Base
- CAS编号：
- 包装：1 mg
- 价格：1333元
- 更新日期：2024/04/30
- 产品编号：HY-18332C
- 产品名称：1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 DOV-216,303 Free Base
- CAS编号：66504-40-3
- 包装：5mg
- 价格：3500元
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6124
- 优势度：58
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