生物活性 体内研究 N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate 试剂级价格
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ChemicalBook  CAS数据库列表  N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

生物活性 体内研究 N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate 试剂级价格
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate,191868-14-1,结构式
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
  • CAS号:191868-14-1
  • 英文名:N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
  • 中文名:N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
  • CBNumber:CB32518838
  • 分子式:C31H36F3N7O5
  • 分子量:643.67
  • MOL File:191868-14-1.mol
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate化学性质
  • 储存条件 :Store at +4°C
  • 溶解度 :<75.77mg/ml in DMSO; <75.77mg/ml in ethanol
  • 形态 :solid
  • 颜色 :White

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate性质、用途与生产工艺

  • 生物活性 BIBO3304 TFA 是一种高效的、具有口服活性的、选择性的神经肽Y (NPY) Y1 受体拮抗剂，对人和大鼠 Y1 受体均具有高亲和力 (IC50 分别为 0.38 和 0.72 nM)。
  • 体内研究

    BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.
    BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.
    BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels.

    Animal Model: Adult male Chbb:Thom rats weighing between 300 and 340 g
    Dosage: 30 μg
    Administration: bilateral paraventricular nucleus injection
    Result: Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.
    Animal Model: 7-week-old C57BL/6JAusb mice
    Dosage: 0.5 μM
    Administration: p.o.
    Result: Significantly increased serum insulin levels.
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate上下游产品信息
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下游产品
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-107725
  • 产品名称：BIBO3304 TFA
  • CAS编号：
  • 包装：1 mg
  • 价格：1047元
  • 更新日期：2024/11/08
  • 产品编号：HY-107725
  • 产品名称：N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate BIBO3304 TFA
  • CAS编号：191868-14-1
  • 包装：5mg
  • 价格：2488元
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate生产厂家
  • 公司名称：TOCRIS-US
  • 联系电话：--
  • 电子邮件：customerservice@tocris.co.uk
  • 国家：英国
  • 产品数：5726
  • 优势度：77
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