ChemicalBook CAS数据库列表 STAT5 Inhibitor
STAT5 Inhibitor
- CAS号:285986-31-4
- 英文名:STAT5 Inhibitor
- 中文名:STAT5 Inhibitor
- CBNumber:CB32515923
- 分子式:C16H11N3O3
- 分子量:293.28
- MOL File:285986-31-4.mol
STAT5 Inhibitor化学性质
- 熔点 :214-216 °C
- 密度 :1.33±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C(protect from light)
- 溶解度 :≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- 形态 :crystalline solid
- 酸度系数(pKa) :10.44±0.46(Predicted)
- 颜色 :White to light yellow
STAT5 Inhibitor性质、用途与生产工艺
- 生物活性 STAT5-IN-1 是一种有效的选择性 STAT5 抑制剂,其对于STAT5β亚型的IC50值为47 μM。
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靶点
Target Value STAT5β
(Cell-free assay)47 μM -
体外研究
The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.
STAT5 Inhibitor上下游产品信息
上游原料
下游产品
STAT5 Inhibitor 试剂级价格
- 更新日期:2024/11/08
- 产品编号:HY-101853
- 产品名称:STAT5 Inhibitor STAT5-IN-1
- CAS编号:285986-31-4
- 包装:5mg
- 价格:550元
- 更新日期:2024/11/08
- 产品编号:HY-101853
- 产品名称:STAT5 Inhibitor STAT5-IN-1
- CAS编号:285986-31-4
- 包装:10mM * 1mLin DMSO
- 价格:605元
STAT5 Inhibitor生产厂家
- 公司名称:A.J Chemicals
- 联系电话:--
- 电子邮件:sales@ajchem.in
- 国家:印度
- 产品数:6100
- 优势度:58