GALANIN (1-13) - BRADYKININ (2-9) AMIDE

GALANIN (1-13) - BRADYKININ (2-9) AMIDE化学性质

安全信息

GALANIN (1-13) - BRADYKININ (2-9) AMIDE性质、用途与生产工艺

生物活性 Galanin Receptor Ligand M35 是一种高亲和力的甘丙肽受体 (galanin receptor) 配体 (Kd=0.1 nM)，也是 galanin receptor 拮抗剂。Galanin Receptor Ligand M35 对人甘丙肽受体 1 型和人甘丙肽受体 2 型的 Ki 值分别为 0.11 nM、2.0 nM。
靶点

Kd: 0.1 nM (galanin receptor)
Ki: 0.11 nM (human galanin receptor type 1), 2.0 nM (human galanin receptor type 2)
体外研究

Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP.
体内研究

Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task.

GALANIN (1-13) - BRADYKININ (2-9) AMIDE上下游产品信息

上游原料

下游产品

GALANIN (1-13) - BRADYKININ (2-9) AMIDE生产厂家

142846-71-7, GALANIN (1-13) - BRADYKININ (2-9) AMIDE相关搜索: