盐酸奈替康唑
- CAS号:130773-02-3
- 英文名:Neticonazole Hydrochloride
- 中文名:盐酸奈替康唑
- CBNumber:CB31480006
- 分子式:C17H23ClN2OS
- 分子量:338.9
- MOL File:130773-02-3.mol
- 熔点 :145-147°
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 250 mg/mL (737.68 mM)
- 形态 :Solid
- 颜色 :White to off-white
盐酸奈替康唑性质、用途与生产工艺
- 生物活性 Neticonazole是咪唑类抗真菌剂，用于治疗皮肤真菌感染。
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靶点
Fungal
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体外研究
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.
Western Blot Analysis
Cell Line: C4-2B cells Concentration: 10 µM Incubation Time: 48 hours Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. -
体内研究
Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg Administration: Oral gavage; daily; for 15 days Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.
- 更新日期：2024/11/08
- 产品编号：HY-128365
- 产品名称：盐酸奈替康唑 Neticonazole hydrochloride
- CAS编号：130773-02-3
- 包装：25mg
- 价格：650元
- 更新日期：2024/11/08
- 产品编号：HY-128365
- 产品名称：盐酸奈替康唑 Neticonazole hydrochloride
- CAS编号：130773-02-3
- 包装：50mg
- 价格：950元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
