8-O-乙酰山栀苷甲酯

生物活性靶点体外研究体内研究 8-O-乙酰山栀苷甲酯试剂级价格

8-O-乙酰山栀苷甲酯

CAS号:57420-46-9
英文名:8-O-acetyl shanzhiside methyl ester
中文名:8-O-乙酰山栀苷甲酯
CBNumber:CB31377841
分子式:C19H28O12
分子量:448.42
MOL File:57420-46-9.mol

8-O-乙酰山栀苷甲酯化学性质

沸点 :634.2±55.0 °C(Predicted)
密度 :1.52
溶解度 :Soluble in methan
形态 :powder
酸度系数(pKa) :12.80±0.70(Predicted)
颜色 :White

安全信息

安全说明 :24/25
海关编码 :29389090

8-O-乙酰山栀苷甲酯性质、用途与生产工艺

生物活性 Barlerin (8-O-Acetyl shanzhiside methyl ester) 是从中国西藏民间药用植物中分离出的环孢菌素葡萄糖苷。Barlerin (8-O-Acetyl shanzhiside methyl ester) 可以抑制 NF-κB 活性。
靶点
Target Value
NF-κB
()
体外研究

Treatment of SH-SY5Y cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 (HMGB-1) expression. . Treatment of H9c2 cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.
体内研究

Barlerin (8-O-Acetyl shanzhiside methyl ester) 40 mg/kg demonstrates significant neuroprotective effect even after delayed administration at 4 hr after I/R. Barlerin 40 mg/kg attenuates the histopathological damage, decreases brain swelling, inhibits NF-κB activation and reduces HMGB-1 expression in ischaemic brain tissue. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. Barlerin also significantly increases vascularization compared with vehicle treatment. It increases the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time, prothrombin time or thrombin time. It significantly prolongs euglobulin clot lysis time in hyperfibrinolysis mice.
化学性质类白色结晶粉末，易溶于甲醇乙醇，来源于独一味。
用途 8-O-乙酰山栀苷甲酯具有止血镇痛的作用。
用途用于含量测定/鉴定/药理实验等。
药理药效:有活化淤血、止痛止血。