化合物RO 5-3335
- CAS号:30195-30-3
- 英文名:Ro 5-3335
- 中文名:化合物RO 5-3335
- CBNumber:CB31365501
- 分子式:C13H10ClN3O
- 分子量:259.69
- MOL File:30195-30-3.mol
- 熔点 :256 °C(dec.)
- 溶解度 :Soluble to 100 mM in DMSO
- 形态 :powder to crystal
- 颜色 :White to Light red to Green
- 海关编码 :2933.99.8290
化合物RO 5-3335性质、用途与生产工艺
- 生物活性 Ro5-3335 是一种苯二氮化合物，能作为核心结合因子 (CBF) 白血病抑制剂。Ro5-3335 是 RUNX1-CBFβ 相互作用抑制剂，可抑制 RUNX1/CBFB 依赖性反式激活。
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靶点
RUNX1-CBFβ interaction
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体外研究
Ro5-3335 has antiproliferative activity against human CBF leukemia cell lines, with IC 50 s of 1.1 μM, 21.7 μM and 17.3 μM for ME-1, Kasumi-1 and REH, respectively.
Ro5-3335 inhibits definitive hematopoiesis in zebrafish embryos.
Ro5-3335 does not completely break apart RUNX1-CBFβ interaction, but changes the conformation of their complex or increases the distance between RUNX1 and CBFβ in the complex.
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体内研究
Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models.
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish.
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model.
Animal Model: C57BL/6 mice (leukemic model) Dosage: 300 mg/kg Administration: Oral administration; daily; for 30 days Result: Reduced the number of c-kit + cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen.
- 更新日期：2024/11/08
- 产品编号：HY-108470
- 产品名称：Ro5-3335
- CAS编号：
- 包装：1 mg
- 价格：545元
- 更新日期：2024/11/08
- 产品编号：HY-108470
- 产品名称：化合物RO 5-3335 Ro5-3335
- CAS编号：30195-30-3
- 包装：5mg
- 价格：1200元
- 公司名称：TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话：03-36680489
- 电子邮件：Sales-JP@TCIchemicals.com
- 国家：日本
- 产品数：28387
- 优势度：80
