猩红酸
- CAS号:134-47-4
- 英文名:6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)
- 中文名:猩红酸
- CBNumber:CB2855268
- 分子式:C21H16N2O9S2
- 分子量:504.49
- MOL File:134-47-4.mol
- 密度 :1.798±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :DMSO: 83.33 mg/mL (165.18 mM)
- 酸度系数(pKa) :-0.17±0.40(Predicted)
- 形态 :Solid
- 颜色 :Light brown to brown
- CAS 数据库 :134-47-4(CAS DataBase Reference)
- EPA化学物质信息 :7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] (134-47-4)
猩红酸性质、用途与生产工艺
- 生物活性 AMI-1 free acid 是一种有效的，细胞渗透性的，可逆的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50 值分别为 8.8 μM 和 3.0 μM。AMI-1 free acid 通过阻断肽-底物结合对 PRMTs 发挥抑制作用。
-
靶点
Target Value HMT
()human PRMT1
()yeast Hmt1p
(Cell-free assay)3.0 μM -
体外研究
AMI-1 free acid can inhibit the in vitro methylation reactions performed by all five recombinantly active PRMTs (PRMT1, -3, -4, and -6 and Hmt1p).
AMI-1 free acid not only inhibits type I PRMTs (PRMT1, 3, 4 and 6) but also type II PRMT5.
AMI-1 free acid specifically inhibits arginine, but not lysine, methyltransferase activity in vitro and does not compete for the AdoMet binding site.
AMI-1 free acid inhibits methylation of GFP-Npl3 and cellular proteins.
AMI-1 free acid (0.6-2.4 mM; 48-96 hours) inhibits the cell viability of sarcoma in S180 and U2OS cells in a time-dependent and dose-dependent manner in vitro.
AMI-1 free acid (1.2-2.4 mM; 48-72 hours) reduces S180 cell viability through the induction of cell apoptosis.
Cell Viability Assay
Cell Line: S180 cells, U2OS cells Concentration: 0.6 mM, 1.2 mM, 2.4 mM Incubation Time: 48 hours, 72 hours, 96 hours Result: Inhibited the cell viability. Apoptosis Analysis
Cell Line: S180 cells Concentration: 1.2 mM, 2.4 mM Incubation Time: 48 hours, 72 hours Result: Increased the percentages of cells undergoing apoptosis. -
体内研究
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo.
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model.
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model.
Animal Model: 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft Dosage: 0.5 mg Administration: Intratumorally, daily, for 7 days Result: Decreased tumor weight. - 用途 为偶氮染料用的中间体，用于制造直接橙S、直接耐酸大红4BS等
- 更新日期：2024/11/08
- 产品编号：HY-18962A
- 产品名称：猩红酸 AMI-1 free acid
- CAS编号：134-47-4
- 包装：5mg
- 价格：187元
- 更新日期：2024/11/08
- 产品编号：HY-18962A
- 产品名称：猩红酸 AMI-1 free acid
- CAS编号：134-47-4
- 包装：10mg
- 价格：300元
- 公司名称：kemikalieimport
- 联系电话：--
- 电子邮件：Sales@kemikalieimport.dk
- 国家：欧洲
- 产品数：6685
- 优势度：47
