达巴万星盐酸盐
- CAS号:2227366-51-8
- 英文名:Dalbavancin hydrochloride
- 中文名:达巴万星盐酸盐
- CBNumber:CB28029346
- 分子式:C88H101Cl3N10O28
- 分子量:1853.17
- MOL File:2227366-51-8.mol
- 储存条件 :under inert gas (nitrogen or Argon) at 2-8°C
- 溶解度 :DMSO: ≥ 24 mg/mL (12.95 mM)
- 形态 :Solid
- 颜色 :White to light yellow
- 水溶解性 :Water: 50 mg/mL (26.98 mM)
达巴万星盐酸盐性质、用途与生产工艺
- 生物活性 Dalbavancin hydrochloride(MDL-63397 hydrochloride) 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌具有有效的杀菌活性。Dalbavancin hydrochloride 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90 分别为 0.06 μg/mL 和 0.25 μg/mL。
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体外研究
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
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体内研究
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B. anthracis Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg Administration: Intraperitoneal injection; every 36 h or 72 h; for 14 days Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
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