西他苯

生物活性体外研究体内研究西他苯试剂级价格

西他苯

CAS号:55986-43-1
英文名:CETABEN
中文名:西他苯
CBNumber:CB2752657
分子式:C23H39NO2
分子量:361.56
MOL File:55986-43-1.mol

西他苯化学性质

沸点 :503.4±33.0 °C(Predicted)
密度 :0.979±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
形态 :crystalline solid
酸度系数(pKa) :4.76±0.10(Predicted)
颜色 :White to off-white

西他苯性质、用途与生产工艺

生物活性 Cetaben 是一种不依赖 PPARα 的过氧化物酶体增殖物。Cetaben 是一种非纤维化降血脂药，可有效降低胆固醇和甘油三酸酯的浓度。
体外研究

Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.
Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells.

体内研究

Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg.

Animal Model:	Male Wistar rats
Dosage:	10,25,50,100,250 and 500 mg/kg
Administration:	Gavage; 10 day
Result:	Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg.