ChemicalBook CAS数据库列表 依他普仑
依他普仑
- CAS号:128196-01-0
- 英文名:Escitalopram
- 中文名:依他普仑
- CBNumber:CB2712918
- 分子式:C20H21FN2O
- 分子量:324.39
- MOL File:128196-01-0.mol
依他普仑化学性质
- 比旋光度 :D +12.33° (c = 1 in methanol)
- 沸点 :428.3±45.0 °C(Predicted)
- 密度 :1.18±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :Soluble in DMSO
- 形态 :Powder
- 酸度系数(pKa) :9.57±0.28(Predicted)
- 颜色 :Off-white to light yellow
- CAS 数据库 :128196-01-0(CAS DataBase Reference)
安全信息
依他普仑性质、用途与生产工艺
- 生物活性 Escitalopram ((S)-Citalopram) 是外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂 (SSRI)，Ki 为 0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。Escitalopram 对多巴胺转运体 (DAT) 和去甲肾上腺素转运体 (NET) 均有选择性。Escitalopram 是研究抑郁症的抗抑郁药。
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靶点
Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)
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体内研究
Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats.
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively .Animal Model: Male Sprague-Dawley rats Dosage: 10 mg/kg Administration: I.p.; daily for 28 days Result: Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats. Animal Model: APP-PS1 hemizygous female mice (4 months of age) Dosage: 2.5-5 mg/kg Administration: Daily; drinking water for a total of 4 months Result: At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.
依他普仑上下游产品信息
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依他普仑 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-14258
- 产品名称：Escitalopram
- CAS编号：
- 包装：5 mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-14258
- 产品名称：依他普仑 Escitalopram
- CAS编号：
- 包装：10 mM * 1 mLin DMSO
- 价格：550元
依他普仑生产厂家
- 公司名称：TLC PharmaChem Inc.
- 联系电话：--
- 电子邮件：research@tlcpharmachem.com
- 国家：加拿大
- 产品数：921
- 优势度：60
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
- 公司名称：SYNFINE
- 联系电话：--
- 电子邮件： research@synfine.com.
- 国家：加拿大
- 产品数：768
- 优势度：42
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