羟嗪

羟嗪化学性质

熔点 :190°C
沸点 :250 °C(Press: 0.1 Torr)
密度 :1.1020 (rough estimate)
折射率 :1.5400 (estimate)
储存条件 :2-8°C
溶解度 :Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly,
形态 :Oil to Gel
酸度系数(pKa) :pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)
颜色 :Colourless to Yellow
水溶解性 :< 700 mg/mL
BCS Class :2
NIST化学物质信息 :Hydroxyzine base(68-88-2)
EPA化学物质信息 :Hydroxyzine (68-88-2)

安全信息

羟嗪 MSDS

1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)

生物活性 Hydroxyzine，一种苯二氮卓抗组胺剂 (antihistamine)，作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用，可用于广泛性焦虑障碍的研究。
靶点

H ₁ Receptor
体外研究

Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
体内研究

Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.

羟嗪上下游产品信息

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下游产品

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