羟嗪
- CAS号:68-88-2
- 英文名:Hydroxyzine
- 中文名:羟嗪
- CBNumber:CB2547530
- 分子式:C21H27ClN2O2
- 分子量:374.9
- MOL File:68-88-2.mol
羟嗪化学性质
- 熔点 :190°C
- 沸点 :250 °C(Press: 0.1 Torr)
- 密度 :1.1020 (rough estimate)
- 折射率 :1.5400 (estimate)
- 储存条件 :2-8°C
- 溶解度 :Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly,
- 形态 :Oil to Gel
- 酸度系数(pKa) :pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)
- 颜色 :Colourless to Yellow
- 水溶解性 :< 700 mg/mL
- BCS Class :2
- NIST化学物质信息 :Hydroxyzine base(68-88-2)
- EPA化学物质信息 :Hydroxyzine (68-88-2)
安全信息
- 毒害物质数据 :68-88-2(Hazardous Substances Data)
- 毒性 :LD50 oral in rat: 840mg/kg
羟嗪 MSDS
1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)
羟嗪性质、用途与生产工艺
- 生物活性 Hydroxyzine，一种苯二氮卓抗组胺剂 (antihistamine)，作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用，可用于广泛性焦虑障碍的研究。
-
靶点
H 1 Receptor
-
体外研究
Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
-
体内研究
Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
羟嗪上下游产品信息
上游原料
下游产品
羟嗪 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-B0548
- 产品名称：Hydroxyzine
- CAS编号：
- 包装：100 mg
- 价格：650元
羟嗪生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
68-88-2, 羟嗪相关搜索:
