BM635

MIC50: 0.12 μM (M. tuberculosis H37Rv)

BM635 has potent MIC (0.12 µM), Tox ₅₀ :MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED ₉₉ of 49 mg/Kg (IC _95% : 43–54 mg/Kg). The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (C _max =1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo .