肉豆蔻油酸

生物活性体外研究体内研究肉豆蔻油酸试剂级价格

肉豆蔻油酸

CAS号:544-64-9
英文名:MYRISTOLEIC ACID
中文名:肉豆蔻油酸
CBNumber:CB2447081
分子式:C14H26O2
分子量:226.35
MOL File:544-64-9.mol

肉豆蔻油酸化学性质

熔点 :−4.5-−4 °C(lit.)
沸点 :144 °C0.6 mm Hg(lit.)
密度 :0.9 g/mL at 25 °C(lit.)
折射率 :n20/D 1.4562(lit.)
闪点 :62 °C
储存条件 :-20°C
溶解度 :Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)
形态 :Liquid
酸度系数(pKa) :4.78±0.10(Predicted)
颜色 :Colourless
LogP :5.383 (est)
EPA化学物质信息 :9-Tetradecenoic acid, (9Z)- (544-64-9)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36
危险品运输编号 :NA 1993 / PGIII
WGK Germany :3

肉豆蔻油酸性质、用途与生产工艺

生物活性 Myristoleic acid 是 Serenoa repens 提取物中的一种细胞毒性成分，可诱导人前列腺细胞的凋亡和坏死。

体外研究

Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells.
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation.

Cell Proliferation Assay

Cell Line:	Human prostatic carcinoma LNCaP cells.
Concentration:	0, 50, 100, 150, 200, 250 μg/mL.
Incubation Time:	24 h.
Result:	When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively.

体内研究

Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice.

Animal Model:	C57BL/6 mice at 5 weeks.
Dosage:	0.2, 2 mg/kg
Administration:	IP every 24 h for 4 days.
Result:	Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner.