ChemicalBook CAS数据库列表 肉豆蔻油酸
肉豆蔻油酸
- CAS号:544-64-9
- 英文名:MYRISTOLEIC ACID
- 中文名:肉豆蔻油酸
- CBNumber:CB2447081
- 分子式:C14H26O2
- 分子量:226.35
- MOL File:544-64-9.mol
肉豆蔻油酸化学性质
- 熔点 :−4.5-−4 °C(lit.)
- 沸点 :144 °C0.6 mm Hg(lit.)
- 密度 :0.9 g/mL at 25 °C(lit.)
- 折射率 :n
20/D 1.4562(lit.) - 闪点 :62 °C
- 储存条件 :-20°C
- 溶解度 :Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)
- 形态 :Liquid
- 酸度系数(pKa) :4.78±0.10(Predicted)
- 颜色 :Colourless
- LogP :5.383 (est)
- EPA化学物质信息 :9-Tetradecenoic acid, (9Z)- (544-64-9)
安全信息
肉豆蔻油酸性质、用途与生产工艺
- 生物活性 Myristoleic acid 是 Serenoa repens 提取物中的一种细胞毒性成分，可诱导人前列腺细胞的凋亡和坏死。
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体外研究
Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells.
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation.
Cell Proliferation Assay
Cell Line: Human prostatic carcinoma LNCaP cells. Concentration: 0, 50, 100, 150, 200, 250 μg/mL. Incubation Time: 24 h. Result: When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively. -
体内研究
Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice.
Animal Model: C57BL/6 mice at 5 weeks.
Dosage: 0.2, 2 mg/kg Administration: IP every 24 h for 4 days. Result: Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner.
肉豆蔻油酸上下游产品信息
上游原料
下游产品
肉豆蔻油酸 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-113332
- 产品名称：肉豆蔻油酸 Myristoleic acid
- CAS编号：544-64-9
- 包装：100mg
- 价格：1800元
- 更新日期：2022/04/29
- 产品编号：HY-113332
- 产品名称：肉豆蔻油酸 Myristoleic acid
- CAS编号：544-64-9
- 包装：50mg
- 价格：4000元
肉豆蔻油酸生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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