2,3-双(4-羟苯基)丙腈
- CAS号:1428-67-7
- 英文名:2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
- 中文名:2,3-双(4-羟苯基)丙腈
- CBNumber:CB2379797
- 分子式:C15H13NO2
- 分子量:239.27
- MOL File:1428-67-7.mol
- 熔点 :200.0 to 204.0 °C
- 沸点 :449.4±35.0 °C(Predicted)
- 密度 :1.256±0.06 g/cm3(Predicted)
- RTECS号 :UG0900000
- 储存条件 :-20°C
- 溶解度 :DMSO: soluble10mg/mL, clear
- 形态 :powder
- 酸度系数(pKa) :9.41±0.26(Predicted)
- 颜色 :white to beige
- 水溶解性 :Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C).
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
2,3-双(4-羟苯基)丙腈性质、用途与生产工艺
- 生物活性 DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ 选择性配体，其 EC50 值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。
-
靶点
ERβ
0.85 nM (EC 50 )
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体外研究
DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC 50 =0.85 nM for ERβ; EC 50 =66 nM for ERα).
DPN (10 nM) prevents morphological alterations from Aβ 1-42 (10 μM)-induced toxicity in cultured cortical neurons.
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.
DPN (0.1-100 nM) significantly reduces Aβ 1-42 -stimulated expression of Bax in a non-dose dependent manner.
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ 1-42 treatment on cultured cortical neurons.
DPN (0.1-100 nM) suppresses the Aβ 1-42 -upregulated phosphorylation of JNK and p38.
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体内研究
DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.
Animal Model: Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models Dosage: 10 μg/rat Administration: Subcutaneous injections, daily, for 11 days Result: Increased swimming and decreased immobility in the FST.
- 更新日期：2024/11/08
- 产品编号：B4385
- 产品名称：2,3-双(4-羟苯基)丙腈 2,3-Bis(4-hydroxyphenyl)propionitrile
- CAS编号：1428-67-7
- 包装：10mg
- 价格：480元
- 更新日期：2024/11/08
- 产品编号：B4385
- 产品名称：2,3-双(4-羟苯基)丙腈 2,3-Bis(4-hydroxyphenyl)propionitrile
- CAS编号：1428-67-7
- 包装：50mg
- 价格：1795元
- 公司名称：TCI Europe
- 联系电话：320-37350700
- 电子邮件：sales@tcieurope.eu
- 国家：欧洲
- 产品数：23671
- 优势度：75
- 公司名称：Labinova AB
- 联系电话：--
- 电子邮件：info@labinova.se
- 国家：欧洲
- 产品数：281
- 优势度：64
