133406-29-8
- CAS号:133406-29-8
- 英文名:ST034307
- 中文名:133406-29-8
- CBNumber:CB23356179
- 分子式:C10H4Cl4O2
- 分子量:297.95
- MOL File:133406-29-8.mol
- 沸点 :329.1±42.0 °C(Predicted)
- 密度 :1.674±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
- 形态 :solid
- 颜色 :Yellow
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
133406-29-8性质、用途与生产工艺
- 生物活性 ST034307 是一种有效的，选择性的 adenylyl cyclase 1 抑制剂，IC50 值为 2.3 μM。
-
靶点
IC50: 2.3 μM (AC1)
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体外研究
ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca 2+ /calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.
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体内研究
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E 50 ) value for analgesia of 0.28 μg in the mouse pain model.
- 更新日期：2024/11/08
- 产品编号：HY-101279
- 产品名称：133406-29-8 ST034307
- CAS编号：133406-29-8
- 包装：5mg
- 价格：770元
- 更新日期：2024/11/08
- 产品编号：HY-101279
- 产品名称：133406-29-8 ST034307
- CAS编号：133406-29-8
- 包装：10mM * 1mLin DMSO
- 价格：847元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
