FW1256
- CAS号:117089-08-4
- 英文名:FW1256
- 中文名:FW1256
- CBNumber:CB23335176
- 分子式:C12H10NOPS
- 分子量:247.25
- MOL File:117089-08-4.mol
- 熔点 :139-142 °C
- 沸点 :376.3±25.0 °C(Predicted)
- 密度 :1.37±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: ≥ 250 mg/mL (1011.12 mM)
- 酸度系数(pKa) :-0.88±0.20(Predicted)
FW1256性质、用途与生产工艺
- 生物活性 FW1256 是一种苯基类似物,也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性,并可诱导细胞凋亡 (apoptosis),具有有效的抗炎作用,并可用于癌症和心血管疾病的研究。
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体外研究
FW1256 (200 µM; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS mRNA and protein in LPS-stimulated RAW264.7 macrophages.
FW1256 (200 µM; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS PROTE and protein in LPS-stimulated RAW264.7 macrophages.
FW1256 concentration dependently decreases TNF-α (IC 50 of 61.2 µM), IL-6 (IC 50 of 11.7 µM), PGE2 (IC 50 of 25.5 µM) and NO (IC 50 of 34.6 µM) generation in LPS-stimulated RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs) (IC 50 s of 414.9 µM, 300.2 µM, 4 µM and 9.5 µM for TNF-α, IL-6, PGE2 and NO, respectively) .
FW1256 decreases NF-κB activation as evidenced by reduced cytosolic phospho-IκBα levels and reduces nuclear p65 levels in LPS-stimulated RAW264.7 macrophages treated with FW1256.RT-PCR
Cell Line: RAW264.7 cells Concentration: 200 µM Incubation Time: 24.5 hours Result: Significantly reduced IL-1β, COX-2 and iNOS mRNA in LPS-stimulated RAW264.7 macrophages.. Western Blot Analysis
Cell Line: RAW264.7 cells Concentration: 200 µM Incubation Time: 24.5 hours Result: Significantly reduced IL-1β, COX-2 and iNOS proteinin LPS-stimulated RAW264.7 macrophages.. -
体内研究
FW1256 (100 mg/kg; intraperitoneal injection; male C57BL/6 mice) treatment reduces IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice.
Animal Model: Male C57BL/6 mice (20-25 g, 6-10 weeks) injected with E. coli lipopolysaccharide (LPS) Dosage: 100 mg/kg Administration: Intraperitoneal injection Result: Reduced IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice.
- 更新日期:2024/04/30
- 产品编号:HY-121955
- 产品名称:FW1256
- CAS编号:
- 包装:1 mg
- 价格:1280元
- 更新日期:2024/04/30
- 产品编号:HY-121955
- 产品名称:FW1256 FW1256
- CAS编号:117089-08-4
- 包装:5mg
- 价格:3200元
- 公司名称:北京普西唐生物科技有限公司
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- 公司名称:TargetMol Chemicals Inc.
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- 公司名称:Aladdin Scientific Corporation
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