Prodipine (hydrochloride)
- CAS号:31314-39-3
- 英文名:Prodipine (hydrochloride)
- 中文名:Prodipine (hydrochloride)
- CBNumber:CB23175574
- 分子式:C20H26ClN
- 分子量:315.89
- MOL File:31314-39-3.mol
- 熔点 :267°
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 颜色 :Off-white to yellow
- 海关编码 :2933399990
Prodipine (hydrochloride)性质、用途与生产工艺
- 生物活性 Prodipine 是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶 IV (DPP IV),IC50 分别为 4.5 μM 和 30 μM。
-
靶点
IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV)
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体外研究
Prodipine, a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC 50 values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively.
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体内研究
Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remaines unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery.
- 更新日期:2024/08/19
- 产品编号:HY-101605
- 产品名称:Prodipine (hydrochloride) Prodipine hydrochloride
- CAS编号:31314-39-3
- 包装:1 mg
- 价格:1000元
- 更新日期:2024/08/19
- 产品编号:HY-101605
- 产品名称:Prodipine hydrochloride
- CAS编号:
- 包装:5 mg
- 价格:2500元
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