3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
- CAS号:2003260-55-5
- 英文名:Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- 中文名:3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
- CBNumber:CB23146688
- 分子式:C25H22N2O2
- 分子量:382.45
- MOL File:2003260-55-5.mol
- 沸点 :646.9±55.0 °C(Predicted)
- 密度 :1?+-.0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM) - 形态 :A crystalline solid
- 酸度系数(pKa) :4.81±0.40(Predicted)
- 颜色 :Light yellow to green yellow
3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺性质、用途与生产工艺
- 生物活性 NCGC00244536是高效的 KDM4B 抑制剂，IC50 值为10 nM。
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靶点
IC50: 10 nM (KDM4B)
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体外研究
NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.
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体内研究
Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.
- 更新日期：2024/11/08
- 产品编号：HY-101799
- 产品名称：3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺 NCGC00244536
- CAS编号：2003260-55-5
- 包装：1mg
- 价格：1100元
- 更新日期：2024/11/08
- 产品编号：HY-101799
- 产品名称：3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺 NCGC00244536
- CAS编号：2003260-55-5
- 包装：10mM * 1mLin DMSO
- 价格：2777元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
