PD-1

生物活性靶点体外研究体内研究 PD-1 试剂级价格

PD-1

CAS号:1675201-83-8
英文名:2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
中文名:PD-1
CBNumber:CB23049190
分子式:C29H33NO5
分子量:475.58
MOL File:1675201-83-8.mol

PD-1化学性质

沸点 :630.2±55.0 °C(Predicted)
密度 :1.182±0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
酸度系数(pKa) :2.34±0.20(Predicted)
形态 :solid
颜色 :White
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

PD-1性质、用途与生产工艺

生物活性 BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1)是一种PD-1/PD-L1相互作用的小分子化合物抑制剂，IC50为6 nM。
靶点
Target Value
PD-1/PD-L1 interaction
(Cell-free assay) 0.006 μM

体外研究

Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1. BMS-1, a small-molecule immune checkpoint inhibitor of PD-1/PD-L1, can be used as a therapeutic strategy for tumor immunotherapy.

Cell Cytotoxicity Assay

Cell Line:	NK cells and HepG2 cells
Concentration:	1 μM
Incubation Time:	3 days
Result:	Disturbed the interaction between PD-1 and PD-L1.

体内研究

BMS-1 (500 μg/mL; 100 μL; i.p.) significantly slows down tumor growth and prolongs the survival rates in BALB/c mice.

Animal Model:	BALB/c mice
Dosage:	500 μg/mL; 100 μL
Administration:	I.p.
Result:	Administration significantly slowed down tumor growth and prolonged the survival rates.