(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE

生物活性靶点体外研究体内研究 (5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE 试剂级价格

CAS号:78606-80-1
英文名:5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
中文名:(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE
CBNumber:CB2296632
分子式:C8H16O5
分子量:192.21
MOL File:Mol file

(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE化学性质

沸点 :360.8±42.0 °C(Predicted)
密度 :1?+-.0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :H2O: ≥20mg/mL
酸度系数(pKa) :13.74±0.20(Predicted)
形态 :powder
颜色 :white to beige
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

安全信息

WGK Germany :3

(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE性质、用途与生产工艺

生物活性 BML-111 一种脂蛋白 A4 类似物，是一种脂蛋白 A4 (lipoxin A4) 受体激动剂。BML-111 可抑制血管紧张素转化酶 (ACE) 的活性，并增加血管紧张素转化酶 2 (ACE2) 的活性。BML-111 具有抗血管生成，抗肿瘤和抗炎的特性。
靶点

Lipoxin A4 receptor
Angiotensin converting enzyme (ACE)
体外研究

In H22 cells, BML-111 inhibits the production of vascular endothelial growth factor and reduces hypoxia-inducible factor-1α level.
BML-111 inhibits leukotriene B4-induced cellular migration with an IC ₅₀ of 5 nM.

体内研究

BML-111 (1 mg/kg; intraperitoneal injection; for 15 days; male Imprinting Control Region mice) treatment suppresses tumor-related angiogenesis and tumor growth in vivo. BML-111 also enhances the in situ apoptosis while inhibiting macrophage infiltration in tumor tissue.
BML-111 protects LPS-induced acute lung injury and LPS/D-GalN-induced acute liver injury. BML-111 represses the activity of ACE, but increases the activity of ACE2. BML-111 decreases the expression levels of ACE, AngII, and AngII type 1 receptor (AT1R), meanwhile increases the levels of ACE2, angiotensin-(1-7) (Ang-1-7), and Mas.

Animal Model:	Male Imprinting Control Region mice (5-6-week-old,18-22 g) injected with H22 cells
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; injected 5 minutes before and 4 hours after H22 cell inoculation, then every 12 hours for 2 consecutive days, then daily in an additional 3 days and every other day for the last 10 days
Result:	Suppressed tumor-related angiogenesis and tumor growth in vivo.